Radiotherapy plus ERBITUX® Inferior to Radiotherapy plus Cisplatin in HPV-Positive Oropharyngeal Squamous Cell Carcinoma

January 21st, 2019

The RTOG 1016 randomized, phase III trial has demonstrated that among  HPV-positive Oropharyngeal cancer patients, Radiotherapy plus ERBITUX® showed inferior Overall Survival and Progression Free Survival compared with Radiotherapy plus Cisplatin. Because of the substantial morbidity and lifelong toxicities such as dry mouth, difficulty swallowing, and loss of taste associated with Cisplatin chemotherapy and Radiotherapy, ERBITUX® (Cetuximab), an Epidermal Growth Factor Receptor (EGFR) targeted monoclonal antibody  is often considered an alternative to Cisplatin . Based on this first randomized clinical trial specifically designed for patients with HPV-positive Oropharyngeal cancer, Radiotherapy plus Cisplatin should be the standard of care for eligible patients with HPV-positive Oropharyngeal carcinoma.