Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment a randomised open-label trial

SUMMARY: The TROPIC trial (Treatment of Hormone-Refractory Metastatic Prostate Cancer Previously Treated With a docetaxel (TAXOTERE®)- Containing Regimen) involved 755 men in 26 countries with metastatic prostate cancer who were castration resistant. Patients were randomized to receive either Cabazitaxel (JEVTANA®) 25 mg/m2 or Mitoxantrone 12 mg/m2 three times a week and both groups received prednisone 10 mg daily through out the course of their treatment. The combination of JEVTANA® and prednisone resulted in median overall survival of 15.1 months compared to 12.7 months for the Mitoxantrone group. There was a 30% reduction in the risk of death for the JEVTANA® group. This led to the approval of JEVTANA® for the treatment of hormone-refractory metastatic prostate cancer, previously treated with a TAXOTERE® containing regimen. Lancet 2010;376:1147-1154